Defective neutrophil migration in monosomy-7

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Defective neutrophil migration in monosomy-7.

The migration in vitro of neutrophils from six patients with monosomy-7 or partial deletion of the long arm of chromosome 7 was studied by two methods: the Millipore filter assay and the migration under agarose assay. Four of the patients had preleukemia, one had subacute myelomonocytic leukemia, and one polycythemia vera. In four patients, chemotaxis (migration towards a higher concentration o...

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We studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin D-deficient rickets and compared the results with ten healthy controls of matched age. Among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. When compared with controls, the findi...

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Decrease of the major high molecular weight surface glycoprotein of human granulocytes in monosomy-7 associated with defective chemotaxis.

By use of the galactose/NaB3H4 surface labeling technique followed by polyacrylamide slab gel electrophoresis, it is shown that the major labeled surface glycoprotein (GP130) of normal human blood granulocytes is markedly reduced in granulocytes from three patients with a chromosomal abnormality in all or most bone marrow mitoses. The abnormality consisted of monosomy-7 in two and deletion of t...

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Mutations of the ras proto-oncogenes in childhood monosomy 7.

ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative states (MPS). The bone marrow (BM) monosomy 7 syndrome accounts for a large percen...

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Kojima and colleagues (page 786) report a correlation between G-CSF treatment of children with aplastic anemia and evolution to cytogenetic abnormalities and myelodysplasia. How strong is this relationship and how generalizable the conclusions? The Japanese investigators administered high G-CSF doses (close to the adult equivalent of 10 g/kg/d, later thrice weekly) for very long periods (in all...

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ژورنال

عنوان ژورنال: Blood

سال: 1981

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v58.4.739.739